By Brian L. Samuels, John E. Ultmann (auth.), John E. Ultmann, Brian L. Samuels (eds.)

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Extra resources for Annals of Oncology: Official Journal of the European Society for Medical Oncology

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The third important antibody is L26, which was shown by Mason et al. to be directed against the B cell-specific CD20 molecule [17]. The staining results obtained with these antibodies on a large series of HD cases are summarized in Table 4. These data show that in lymphocyte-predominant HD, the B-cell antigen CD20 is expressed at a high density, and there is no expression of the TCR 13 chain [18, 19]. This varies from results seen in other types of HD, which showed a heterogenous pattern of reactivity [19].

Pre- and post-treatment mean lumbar vertebral marrow T 1 of patients studied serially. ). n_•_____P_os_:_-tLre_a_tm_e_nt Fig. 5. Pre- and post-treatment percent T 1 variation of patients studied serially. ). normalisation of T 2 variation was seen in three of the four patients studied serially. Discussion Conventional magnetic resonance imaging is of value in detecting malignant marrow infiltrates [3, 5, 12] and has been shown to be superior to bone marrow scintigraphy in the evaluation of bone marrow status [5].

The influence of potentially significant prognostic factors on complete remission rates and freedom from treatment failure (FFTF) was estimated with the Cox regression model, which permits comparison of treatment outcome for two or more subsets of patients while simultaneously adjusting for the effect of other factors (covariates) in the model. FFTF curves were constructed by the Kaplan-Meier method. FFTF was defined as the time interval between the start of treatment and the failure to achieve a complete remission (CR) or to relapse after CR.

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Annals of Oncology: Official Journal of the European Society by Brian L. Samuels, John E. Ultmann (auth.), John E. Ultmann,
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